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How to Submit Specimens

Protocol for Sending Specimens from CF Patients

  1. Please send "pure" organisms on agar slants. No agar plates or sputum please.
  • Use a suitable shipping method such as the double-mailing containers consisting of an inner aluminum screw-cap receptacle and an outer fiberboard screw-cap mailing case. The outer container should have the sender's and the CF Referral Center’s name, address and contact telephone number. Our address is:

CF Referral Center for Susceptibility & Synergy Studies
College of Physicians & Surgeons of Columbia University
650 West 168th Street
Black Building 4/413
New York, NY 10032

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Please provide us with contact information for the referring physician and clinical microbiology laboratory

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Please complete the antibiogram section for the isolate(s) you are sending to confirm resistance pattern and to facilitate processing. Alternatively, you can send us a print-out copy of the identification and antimicrobial susceptibilities obtained by your laboratory.
  • Modifications to Organisms Accepted for Testing: From January 1st 2008, the scope of work at The Synergy Lab will be modified to only process multidrug-resistant P. aeruginosa and a maximum of 2 requests per patient per year.
  • If multiple strains of P. aeruginosa are recovered from a single patient, please send us the most resistant isolate(s) for testing.
  • We will process P. aeruginosa strains that are :
  • Multidrug-resistant (i.e., resistant to all antimicrobial agents in at least 2 major agent classes; e.g., resistant to all aminoglycosides or resistant to all ß-lactam agents and ciprofloxacin). Please note that this is the same definition of multidrug-resistance used in the CF Microbiology Consensus Document.‡ 
  • Susceptible to ≥1 aminoglycoside agents, but resistant to all β-lactam agents.
  • Susceptible to ≥1 β-lactam agents (including aztreonam, meropenem, or imipenem), but resistant to all aminoglycoside agents.

(We will process an isolate no matter the susceptibility pattern if a patient is failing therapy or has significant drug allergies. We need to be informed of these clinical circumstances when you send the isolate by annotating the patient information form).

  • Send the package by overnight delivery. We have noted that nearly all of our referring centers have had very good experience with jump to FedEx.com!.
  • Results can be obtained from our secure server. We no longer mail printed reports. For further information on how to register on-line or if you need us to guide you through the registration process please contact Luis Alba at (212) 305-3005 or via email at LA2131@columbia.edu.

We will provide faxed reports to end users without internet access.

  • Please feel free to call or email us with any further questions.

†Available as an Adobe® Acrobat® File. Requires Adobe® Acrobat® Reader Get Adobe Acrobat Reader Now!.
If you are unable to download the form, please email or call the CF Referral Center Laboratory at 212-305-1991.
Saiman L, Siegel J, and the CF Foundation Consensus Conference on Infection Control Participants. 2003. Infection control recommendations for patients with cystic fibrosis: microbiology, important pathogens, and infection control practices to prevent patient-to-patient transmission. Infect Control Hosp Epidemiol. 24:S6-52